Docebenone

Docebenone

SCHEMBL522781

CC1=C(C)C(=O)C(CCCCC#CCCCC#CCO)=C(C)C1=O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
LMNA P02545 1/20 0.41
PGR P06401 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
MAOA P21397 1/20 0.41
TBXA2R P21731 1/20 0.41
MAPK1 P28482 1/20 0.41
AVPR2 P30518 1/20 0.41
CYP2C19 P33261 1/20 0.41
HTR2B P41595 1/20 0.41
HTT P42858 1/20 0.41
PDE3A Q14432 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
SLC29A1 Q99808 1/20 0.41
ALOX15 P16050 3/20 0.37
ALDH1A1 P00352 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14684712 0.95 MAPT (0.38) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL15517158 0.94 TDP1 (0.39) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL11093696 0.88 MAPT (0.53) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL11101641 0.88 MAPT (0.49) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL16979623 0.85 MAPT (0.39) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL15520246 0.84 TDP1 (0.42) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL15518487 0.84 TDP1 (0.45) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL11094728 0.83 MAPT (0.64) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL9019294 0.83 MAPT (0.35) MAPTTDP1LMNAPGRCYP3A4
SCHEMBL15518472 0.80 PTPN2 (0.33) MAPTTDP1LMNAPGRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 928 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA PLUTO INC (KR) 2025-10-30 US claimed
WO-2025224119-A1 METHOD OF ENRICHING A CELL POPULATION CONTAINING INTACT AND DAMAGED CELLS IN A LIQUID MEDIUM TrophoSYS GmbH (DE) 2025-10-30 WO claimed
CN-119656319-A Iron death inhibitors for improving liver toxicity of GPR40 agonist TAK-875 张宏全 2025-03-21 CN claimed
EP-4494639-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA Pluto Inc. (KR) 2025-01-22 EP claimed
WO-2024199144-A1 NOVEL REAGENT FOR MITIGATING LNP TOXICITY SHANGHAI MOYIN THERAPEUTICS CO., LTD. (CN) 2024-10-03 WO claimed
US-20240299347-A1 METHODS AND COMPOSITIONS TO TREAT HUNTINGTON'S DISEASE BY TARGETING ALOX5- MEDIATED FERROPTOSIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2024-09-12 US claimed
WO-2023177128-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA 주식회사 플루토 2023-09-21 WO claimed
US-20210275600-A1 METHODS FOR DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES Tets, Viktor Veniaminovich (US) 2021-09-09 US claimed
EP-3400971-B1 ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-08-04 EP claimed
EP-3852774-A1 METHODS FOR DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES Tets, Viktor, Veniaminovich (US) 2021-07-28 EP claimed
EP-0888127-A1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS G.D. SEARLE & CO. (US) 1999-01-07 EP claimed
EP-0833622-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1998-04-08 EP claimed
WO-1997029776-A1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS G.D. SEARLE & CO. (US) 1997-08-21 WO claimed
EP-0750496-A1 USE OF LIPOXYGENASE INHIBITORS AS ANTI-CANCER THERAPEUTIC AND INTERVENTION AGENTS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-01-02 EP claimed
WO-1996041626-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1996-12-27 WO claimed
WO-1995024894-A9 USE OF LIPOXYGENASE INHIBITORS AS ANTI-CANCER THERAPEUTIC AND INTERVENTION AGENTS 1995-10-26 WO claimed
WO-1995024894-A2 USE OF LIPOXYGENASE INHIBITORS AS ANTI-CANCER THERAPEUTIC AND INTERVENTION AGENTS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-09-21 WO claimed
EP-0038160-B1 QUINONE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1984-09-19 EP claimed
US-4393075-A SLOW-REACTING-SUBSTANCE OF ANAPHYLAXIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1983-07-12 US claimed
EP-0038160-A1 Quinone compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1981-10-21 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240299347-A1 METHODS AND COMPOSITIONS TO TREAT HUNTINGTON'S DISEASE BY TARGETING ALOX5- MEDIATED FERROPTOSIS ALOX5, ALOX15, ALOX15B MAPT 1521/4885TDP1 858/4885LMNA 3601/4885
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA MYOF, ALOX5, MYLK2 MAPT 3742/4885TDP1 2982/4885LMNA 2706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.