Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227096 | 0.82 | SMO (0.44) | SMOMAPTPOLBLMNADRD2 | |
| SCHEMBL5224916 | 0.82 | SMO (0.44) | SMOMAPTTP53POLBLMNA | |
| SCHEMBL5226151 | 0.80 | SMO (0.35) | SMOTP53LMNAALDH1A1KDM4E | |
| SCHEMBL5228292 | 0.76 | SMO (0.37) | SMO | |
| SCHEMBL5226715 | 0.75 | ALDH1A1 (0.37) | THRBMAPTTP53POLBLMNA | |
| SCHEMBL5224994 | 0.75 | MAPT (0.35) | THRBMAPTTP53POLBLMNA | |
| SCHEMBL5224670 | 0.71 | NR3C1 (0.35) | SMOLMNAALDH1A1NPSR1 | |
| SCHEMBL5227160 | 0.67 | SMO (0.41) | SMOMAPTLMNADRD2DRD4 | |
| SCHEMBL5225508 | 0.67 | SSTR5 (0.36) | SMOTHRBMAPTTP53LMNA | |
| SCHEMBL2761009 | 0.67 | SMO (0.43) | SMOMAPTTP53LMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |