Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.54 |
| ▸ | CCR8 | P51685 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CCR5 | P51681 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999658 | 0.89 | KDM4E (0.58) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL4490379 | 0.82 | ALDH1A1 (0.42) | TSHRHIF1ATP53L3MBTL1ALDH1A1 | |
| SCHEMBL13978864 | 0.81 | CCR1 (0.58) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL9976751 | 0.80 | CCR1 (0.47) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL12853981 | 0.80 | LMNA (0.68) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL1282008 | 0.80 | CCR1 (0.75) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL30184687 | 0.80 | CCR1 (0.75) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL12914324 | 0.79 | CCR1 (0.54) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL17691834 | 0.78 | CCR1 (0.50) | CCR1CCR8TSHRMAPTCCR5 | |
| SCHEMBL17691989 | 0.78 | CCR1 (0.50) | CCR1CCR8TSHRMAPTCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | claimed |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | claimed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | claimed |
| EP-1506202-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | Pliva-Istrazivacki Institut D.D.O. (HR) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097648-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-11-27 | — | — | WO | claimed |
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | disclosed |
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | disclosed |
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | disclosed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | disclosed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | disclosed |
| CN-1310919-C | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA ISTRAZIVACKI INST D O O (HR) | 2007-04-18 | — | — | CN | disclosed |
| CN-1310919-C | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA ISTRAZIVACKI INST D O O (HR) | 2007-04-18 | — | — | CN | disclosed |
| CN-1668622-A | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA ISTRAZIVACKI INST D O O (HR) | 2005-09-14 | — | — | CN | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| EP-1506202-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | Pliva-Istrazivacki Institut D.D.O. (HR) | 2005-02-16 | — | — | EP | disclosed |
| EP-1506202-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | Pliva-Istrazivacki Institut D.D.O. (HR) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097648-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003097648-A1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARTION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | CCR1 265/4885CCR8 971/4885TSHR 4057/4885 |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | CCR1 275/4885CCR8 1000/4885TSHR 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.