Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237078 | 0.90 | MAPT (0.53) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL24963646 | 0.80 | ACHE (0.59) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL3265528 | 0.78 | HDAC6 (0.47) | KMT2APKMSLC6A7CA12CA1 | |
| SCHEMBL5232026 | 0.76 | SLC6A7 (0.68) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL5238067 | 0.75 | CA12 (0.53) | MAPTALDH1A1HPGDCA12CA2 | |
| SCHEMBL5904089 | 0.75 | PKM (0.60) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL8354208 | 0.74 | ADRB1 (0.78) | ALDH1A1KMT2APKMSLC6A7CA12 | |
| SCHEMBL5237366 | 0.73 | AKR1C3 (0.52) | MAPTALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL5239940 | 0.73 | HIF1A (0.52) | MAPTALDH1A1KMT2ASMN1; SMN2CYP2C9 | |
| SCHEMBL5235991 | 0.73 | KDM4E (0.57) | MAPTALDH1A1HPGDSMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |