Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319290 | 0.74 | HTR2A (0.41) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL3160107 | 0.70 | MTNR1A (0.33) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL5230871 | 0.67 | HTR2A (0.45) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL5102654 | 0.66 | HTR2A (0.52) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL31181454 | 0.65 | HTR2A (0.46) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL5202202 | 0.65 | HTR6 (0.56) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL3943593 | 0.64 | MAPT (0.39) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL5202211 | 0.64 | MTNR1A (0.52) | HTR2AMTNR1AMTNR1BSCN5ASCN2A | |
| SCHEMBL2071662 | 0.64 | MTNR1A (0.42) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL788913 | 0.62 | HTR2A (0.57) | HTR2AHTR2CHTR2BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756054-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118539-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |