Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237005 | 0.84 | P2RX7 (0.43) | MEN1KMT2AFFAR1TDP1LMNA | |
| SCHEMBL5234356 | 0.80 | CYP1A2 (0.47) | MEN1KMT2ACYP1A2LMNAHPGD | |
| SCHEMBL29959944 | 0.80 | CYP1A2 (0.47) | MEN1KMT2ACYP1A2LMNAHPGD | |
| SCHEMBL5238450 | 0.74 | LMNA (0.47) | PTGER1BRD4TDP1LMNAMAPT | |
| SCHEMBL8429673 | 0.72 | DAO (0.46) | FFAR1LMNAMAPTHPGDHTT | |
| SCHEMBL5239308 | 0.71 | FFAR1 (0.41) | MEN1KMT2AFFAR1TDP1LMNA | |
| SCHEMBL979568 | 0.70 | KDM4E (0.61) | PTGER1CYP1A2BRD4TDP1LMNA | |
| SCHEMBL11462750 | 0.70 | KDM4E (0.46) | MEN1KMT2AFFAR1TDP1LMNA | |
| SCHEMBL5237932 | 0.70 | CYP1A2 (0.48) | MEN1KMT2ACYP1A2HPGDADORA2A | |
| SCHEMBL5267623 | 0.70 | MRGPRX4 (0.37) | PTGER1CYP1A2CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |