Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 6/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231082 | 0.88 | ALDH1A1 (0.43) | MAPTTP53ALDH1A1GAAIDH1 | |
| SCHEMBL5233848 | 0.86 | ACLY (0.39) | EPAS1ACLYTP53ALDH1A1IDH1 | |
| SCHEMBL5230424 | 0.83 | ALDH1A1 (0.49) | EPAS1MAPTALDH1A1GAACA1 | |
| SCHEMBL5228196 | 0.82 | CA12 (0.49) | MAPTTP53ALDH1A1GAACA2 | |
| SCHEMBL5237280 | 0.82 | CES1 (0.49) | MAPTALDH1A1IDH1MEN1KMT2A | |
| SCHEMBL5228023 | 0.81 | CA2 (0.49) | MAPTALDH1A1HDAC1CA1CA2 | |
| SCHEMBL5227180 | 0.81 | LMNA (0.43) | EPAS1CA1CA2MMP1MMP2 | |
| SCHEMBL5234203 | 0.80 | ALDH1A1 (0.42) | MAPTALDH1A1GAAIDH1CA1 | |
| SCHEMBL5227591 | 0.80 | CDK1 (0.52) | MAPTALDH1A1GAAIDH1MEN1 | |
| SCHEMBL5227928 | 0.80 | MEN1 (0.50) | EPAS1MAPTALDH1A1GAACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |