Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234753 | 0.83 | DGAT1 (0.41) | PANK3MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5238842 | 0.82 | EGLN1 (0.43) | ACACBGRIN1GRIN2BCRBNALDH1A1 | |
| SCHEMBL5237578 | 0.81 | KDM4E (0.43) | PANK3KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL5238522 | 0.81 | PANK3 (0.43) | PANK3PPARGPPARAGRIN2DGRIN3B | |
| SCHEMBL5237002 | 0.80 | DGAT1 (0.41) | — | |
| SCHEMBL5236952 | 0.80 | EGLN1 (0.46) | NPC1RAB9AKMT2A | |
| SCHEMBL5233798 | 0.79 | AKR1C3 (0.36) | PANK3AKR1C3ACACBPPARGPPARD | |
| SCHEMBL5236765 | 0.79 | CACNA1G (0.39) | ACACBPPARGPPARDPPARAMAPT | |
| SCHEMBL5233010 | 0.77 | MGLL (0.44) | GRIN1GRIN2BKDM4EPOLB | |
| SCHEMBL5236755 | 0.77 | MGLL (0.41) | PANK3MAPTRAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |