Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236266 | 0.86 | MAPT (0.41) | KDM4EMAPTALDH1A1GAATDP1 | |
| SCHEMBL5236214 | 0.83 | RXRA (0.39) | RXRARXRBRXRGMCL1KDM4E | |
| SCHEMBL5236546 | 0.82 | USP2 (0.46) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5236779 | 0.80 | HDAC8 (0.39) | MCL1KDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL5238186 | 0.79 | CYP2C19 (0.43) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5236759 | 0.78 | MCL1 (0.41) | MCL1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5234829 | 0.77 | GRM5 (0.54) | RXRARXRBRXRGMCL1KDM4E | |
| SCHEMBL5232288 | 0.76 | MAPT (0.41) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL5232202 | 0.76 | RAB9A (0.40) | MCL1KDM4EMAPTALDH1A1GAA | |
| SCHEMBL5235440 | 0.76 | ALDH1A1 (0.40) | KDM4EMAPTALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |