Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233951 | 0.90 | MAPT (0.47) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5233512 | 0.86 | MAPT (0.51) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5239244 | 0.85 | ALDH1A1 (0.52) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5236702 | 0.85 | FAAH (0.57) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5234202 | 0.84 | L3MBTL1 (0.68) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL594349 | 0.84 | HRH2 (0.52) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5235029 | 0.83 | GAA (0.52) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5236270 | 0.82 | KMT2A (0.49) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5238043 | 0.82 | CA12 (0.50) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL5235359 | 0.82 | MAPT (0.58) | MAPTGAALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |