Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236271 | 0.88 | ERN1 (0.43) | FFAR1ERN1ALDH1A1MAPK1TP53 | |
| SCHEMBL5234847 | 0.85 | KMT2A (0.40) | ALDH1A1HPGDTP53MAPTHTR1A | |
| SCHEMBL5239486 | 0.84 | FGFR1 (0.41) | ERN1ALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL5236555 | 0.83 | USP2 (0.41) | FFAR4ALDH1A1HPGDMAPK1TP53 | |
| SCHEMBL5233074 | 0.82 | L3MBTL1 (0.44) | ALDH1A1MAPK1MAPTHTR1ALMNA | |
| SCHEMBL5232294 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HPGDTP53MAPTHTR1A | |
| SCHEMBL5236699 | 0.81 | CD274 (0.41) | CD274FFAR4FFAR1PDE4BALDH1A1 | |
| SCHEMBL5233790 | 0.81 | CA2 (0.38) | CD274MAPTLMNA | |
| SCHEMBL5237663 | 0.80 | KCNA5 (0.37) | FFAR4CYP3A4 | |
| SCHEMBL5232205 | 0.80 | SLC6A7 (0.41) | ALDH1A1HPGDMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |