Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236705 | 0.88 | CD274 (0.41) | ERN1MAPTALDH1A1HTR6FFAR1 | |
| SCHEMBL5236214 | 0.86 | RXRA (0.39) | ERN1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5236266 | 0.84 | MAPT (0.41) | ERN1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5236555 | 0.83 | USP2 (0.41) | MAPTALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL5238192 | 0.79 | CYP2C19 (0.37) | MAPTALDH1A1MAPK1KMT2AUSP2 | |
| SCHEMBL5237752 | 0.79 | RXRA (0.44) | MAPTALDH1A1TDP1FFAR1MAPK1 | |
| SCHEMBL5238652 | 0.78 | HSD17B10 (0.44) | ALDH1A1MAPK1KMT2AUSP2MEN1 | |
| SCHEMBL5240799 | 0.78 | NAAA (0.40) | MAPTALDH1A1MAPK1KMT2AUSP2 | |
| SCHEMBL5236998 | 0.78 | KMT2A (0.40) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5232205 | 0.78 | SLC6A7 (0.41) | MAPTKDM4EALDH1A1GAAS1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |