Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 2/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240799 | 0.91 | NAAA (0.40) | KMT2AMEN1RAB9AMGLLALDH1A1 | |
| SCHEMBL5236998 | 0.91 | KMT2A (0.40) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL5236555 | 0.87 | USP2 (0.41) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL5238652 | 0.84 | HSD17B10 (0.44) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL5237980 | 0.84 | CTSK (0.41) | RXRARXRB | |
| SCHEMBL5237744 | 0.83 | RXRA (0.47) | RXRARXRBDHODHKMT2AMEN1 | |
| SCHEMBL5234786 | 0.81 | FFAR4 (0.44) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL5234847 | 0.81 | KMT2A (0.40) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL5235446 | 0.81 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL5238192 | 0.80 | CYP2C19 (0.37) | KMT2AMEN1NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |