Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | HPGD | P15428 | 9/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 18/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 16/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | HBB | P68871 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236555 | 0.90 | USP2 (0.41) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL5238192 | 0.90 | CYP2C19 (0.37) | HSD17B10ALDH1A1MAPK1HIF1AUSP2 | |
| SCHEMBL5236743 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPK1MEN1KMT2ATSHR | |
| SCHEMBL5234716 | 0.88 | ALDH1A1 (0.43) | HSD17B10ALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL5232239 | 0.87 | SCD (0.38) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL5234786 | 0.86 | FFAR4 (0.44) | ALDH1A1USP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5240799 | 0.85 | NAAA (0.40) | HSD17B10ALDH1A1MAPK1HIF1AUSP2 | |
| SCHEMBL5237980 | 0.85 | CTSK (0.41) | — | |
| SCHEMBL5232337 | 0.85 | LMNA (0.45) | ALDH1A1HPGDMAPK1CYP1A2CYP2D6 | |
| SCHEMBL5232205 | 0.85 | SLC6A7 (0.41) | ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |