Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
| ▸ | ME3 | Q16798 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232584 | 0.87 | RXRA (0.59) | MAPTMAPK1PKMKMT2AMEN1 | |
| SCHEMBL5473090 | 0.85 | KMT2A (0.62) | MAPTALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL14207944 | 0.84 | MAPT (0.60) | MAPTMAPK1PKMALDH1A1KMT2A | |
| SCHEMBL27363642 | 0.81 | MAPT (0.65) | MAPTMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17107398 | 0.81 | THRA (0.60) | MAPTALDH1A1HSD17B10GAALMNA | |
| SCHEMBL3319476 | 0.80 | KMT2A (0.47) | MAPTMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL5239162 | 0.79 | MAPT (0.53) | MAPTMAPK1PKMALDH1A1KMT2A | |
| SCHEMBL11058549 | 0.79 | KMT2A (0.51) | MAPTMAPK1PKMALDH1A1KMT2A | |
| SCHEMBL632352 | 0.79 | L3MBTL1 (0.73) | MAPTMAPK1ALDH1A1GAALMNA | |
| SCHEMBL27620090 | 0.78 | MAPT (0.57) | MAPTMAPK1ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |