Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663325 | 0.82 | CRHBP (0.63) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL2816974 | 0.81 | CRHBP (0.61) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL3276362 | 0.79 | TDP1 (0.66) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL30352851 | 0.79 | TDP1 (0.66) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL3559913 | 0.78 | CRHBP (0.68) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL2601600 | 0.78 | CRHBP (0.58) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL15203036 | 0.78 | CRHBP (0.58) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL1897629 | 0.78 | CRHBP (0.58) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL653911 | 0.78 | TDP1 (0.81) | CRHBPCRHR2TDP1POLBALDH1A1 | |
| SCHEMBL3184724 | 0.78 | CRHBP (0.58) | CRHBPCRHR2TDP1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1305846-C | Urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2007-03-21 | — | — | CN | claimed |
| US-20020198376-A1 | Novel urea derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-26 | — | — | US | claimed |
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | claimed |
| CN-1299344-A | Novel urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2001-06-13 | — | — | CN | claimed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | claimed |
| CN-1305846-C | Urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2007-03-21 | — | — | CN | disclosed |
| EP-1507776-B1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-6730784-B2 | AS THERAPEUTIC AGENTS FOR AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| US-20030229068-A1 | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use | AMGEN INC. | 2003-12-11 | — | — | US | disclosed |
| US-20020198376-A1 | Novel urea derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-26 | — | — | US | disclosed |
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | disclosed |
| CN-1299344-A | Novel urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2001-06-13 | — | — | CN | disclosed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |
| US-4980096-A | Protective coatings; adhesives | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-12-25 | — | — | US | disclosed |
| US-4740600-A | UNBLOCKING WITH ACTINIC RADIATION; PROTECTIVE COATING; THERMOPLASTIC RESIN MIXTURES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1988-04-26 | — | — | US | disclosed |
| US-4599273-A | PROTECTIVE COATINGS, PRESSURE SENSITIVE ADHESIVES | MINNESOTA MINING AND MANUFACTURING CO. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4478967-A | Photolabile blocked surfactants and compositions containing the same | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1984-10-23 | — | — | US | disclosed |
| EP-0046083-A2 | Photolabile blocked surfactants and compositions containing the same | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229068-A1 | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use | CASP3, BAX, BAD | CRHBP 4830/4885CRHR2 4400/4885TDP1 428/4885 |
| US-20020198376-A1 | Novel urea derivatives | TNF, CTH, CFH | CRHBP 833/4885CRHR2 194/4885TDP1 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.