Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240923 | 0.86 | RBP4 (0.56) | ALDH1A1KDM4EHPGDMAPTNPC1 | |
| SCHEMBL632352 | 0.82 | L3MBTL1 (0.73) | ALDH1A1KDM4EMAPTGFERL3MBTL1 | |
| SCHEMBL5238406 | 0.81 | L3MBTL1 (0.51) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL5234854 | 0.80 | RAB9A (0.54) | ALDH1A1KDM4EHPGDMAPTL3MBTL1 | |
| SCHEMBL5237364 | 0.79 | TP53 (0.49) | ALDH1A1HPGDMAPTGFERL3MBTL1 | |
| SCHEMBL3767712 | 0.77 | HSD17B10 (0.50) | ALDH1A1KDM4EHSD17B10MAPTGFER | |
| SCHEMBL5232177 | 0.77 | MAPT (0.42) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL5237133 | 0.77 | L3MBTL1 (0.49) | ALDH1A1HSD17B10MAPTL3MBTL1MAPK1 | |
| SCHEMBL5394353 | 0.76 | L3MBTL1 (0.55) | ALDH1A1KDM4EMAPTGFERL3MBTL1 | |
| SCHEMBL4319359 | 0.76 | KMT2A (0.63) | ALDH1A1MAPTGFERNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |