Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233064 | 0.87 | L3MBTL1 (0.48) | MAPTALDH1A1GFERHTTNPC1 | |
| SCHEMBL5239479 | 0.82 | FGFR1 (0.41) | MAPTALDH1A1HSD17B10HPGDGFER | |
| SCHEMBL5234780 | 0.81 | KMT2A (0.46) | MAPTALDH1A1GFERNPC1DRD2 | |
| SCHEMBL5236995 | 0.79 | KMT2A (0.42) | MAPTALDH1A1HSD17B10NPC1ALOX15 | |
| SCHEMBL5237657 | 0.78 | KCNA5 (0.39) | — | |
| SCHEMBL5232202 | 0.78 | RAB9A (0.40) | MAPTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5235440 | 0.77 | ALDH1A1 (0.40) | MAPTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5234836 | 0.77 | MEN1 (0.43) | MAPTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5239166 | 0.77 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5232372 | 0.76 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |