SCHEMBL523935

SCHEMBL523935

CC(C)[Si](Cl)(CCCC#N)C(C)C

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.40
CYP3A4 P08684 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30690932 0.81 TSHR (0.40) TSHRCYP3A4ALDH1A1TDP1
SCHEMBL706925 0.79
SCHEMBL707345 0.79
SCHEMBL715610 0.75
SCHEMBL345296 0.75
SCHEMBL30690955 0.74 TSHR (0.39) TSHRCYP3A4ALDH1A1TDP1
SCHEMBL2101196 0.74 TSHR (0.41) TSHRCYP3A4ALDH1A1TDP1
SCHEMBL523644 0.74
SCHEMBL17666183 0.73 TSHR (0.42) TSHRALDH1A1TDP1
SCHEMBL16724851 0.73 TSHR (0.42) TSHRALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025108961-A1 SOLID ELECTROLYTES AND METHOD FOR MANUFACTURING THE SAME SOLITHOR (BE) 2025-05-30 WO claimed
US-12623205-B2 Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution WATERS TECHNOLOGIES CORPORATION (US) 2026-05-12 US disclosed
US-12611617-B2 Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography WATERS TECHNOLOGIES CORPORATION (US) 2026-04-28 US disclosed
EP-3834927-B1 METHOD FOR PREPARING A SUPERFICIALLY POROUS MATERIAL WATERS TECHNOLOGIES CORP (US) 2026-03-25 EP disclosed
US-20250387778-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2025-12-25 US disclosed
EP-3426390-B1 POROUS MATERIALS WITH CONTROLLED POROSITY AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORP (US) 2025-12-17 EP disclosed
EP-4353682-B1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION, USEFUL FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORP (US) 2025-11-12 EP disclosed
US-20250326936-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM MAXTERIAL INC (US) 2025-10-23 US disclosed
US-20250309344-A1 ALKALI METAL PF6 SALT STABILIZATION IN CARBONATE SOLUTIONS SILATRONIX, INC. (US) 2025-10-02 US disclosed
US-12427502-B2 Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations WATERS TECHNOLOGIES CORPORATION (US) 2025-09-30 US disclosed
US-20060052623-A1 Having two cyclotetrasiloxne rings connected by O-Si groups obtained through hydrolysis and condensation of trifunctional hydrolyzable silicon compounds; functionalization; fireproofing, thermostability, weathproofing, photostability, dielectric, hardness, strength and chemical resistance CHISSO CORPORATION (JP) 2006-03-09 US disclosed
WO-2005034205-A2 SELF ASSEMBLING NANOPARTICLE-POLYMER HYBRIDS DOW CORNING CORPORATION (US) 2005-04-14 WO disclosed
US-20050032084-A1 Method of attaching a biopolymer to a solid support DUKE UNIVERSITY (US) 2005-02-10 US disclosed
US-20040068074-A1 Production process for silsesquioxane derivative having functional group and silsesquioxane derivative JNC CORPORATION (JP) 2004-04-08 US disclosed
US-20020076832-A1 Method of attaching a biopolymer to a solid support DUKE UNIVERSITY 2002-06-20 US disclosed
EP-0962480-A2 Sheet and tube siloxane polymers containing multiple pendent groups DOW CORNING CORPORATION (US) 1999-12-08 EP disclosed
EP-0962481-A2 Sheet and tube siloxane polymers containing a pendent organofunctional group DOW CORNING CORPORATION (US) 1999-12-08 EP disclosed
EP-0269080-B1 SUBSTRATES WITH STERICALLY-PROTECTED, STABLE, COVALENTLY-BONDED ORGANO-SILANE FILMS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-02-27 EP disclosed
EP-0269080-A1 Substrates with sterically-protected, stable, covalently-bonded organo-silane films E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-06-01 EP disclosed
US-4705725-A Substrates with sterically-protected, stable, covalently-bonded organo-silane films E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060052623-A1 Having two cyclotetrasiloxne rings connected by O-Si groups obtained through hydrolysis and condensation of trifunctional hydrolyzable silicon compounds; functionalization; fireproofing, thermostability, weathproofing, photostability, dielectric, hardness, strength and chemical resistance STS, PFAS, POLQ TSHR 2188/4885CYP3A4 489/4885ALDH1A1 2132/4885
US-12611617-B2 Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography F11, F12, F2 TSHR 1076/4885CYP3A4 1642/4885ALDH1A1 493/4885
US-20250309344-A1 ALKALI METAL PF6 SALT STABILIZATION IN CARBONATE SOLUTIONS CA6, MCM6, SLC10A6 TSHR 3534/4885CYP3A4 3241/4885ALDH1A1 4415/4885
US-12623205-B2 Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution ZYX, FGB, F11 TSHR 3099/4885CYP3A4 2602/4885ALDH1A1 4087/4885
US-20250387778-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS C1S, C9, C1R TSHR 4292/4885CYP3A4 1311/4885ALDH1A1 1704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.