Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.44 |
| ▸ | THRA | P10827 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PCNA | P12004 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17479954 | 1.00 | THRB (0.44) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL8448236 | 0.85 | MEN1 (0.54) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL849961 | 0.84 | ALOX15 (0.59) | MEN1KMT2ALMNAPPARGCYP2D6 | |
| SCHEMBL11136076 | 0.84 | ALOX15 (0.59) | MEN1KMT2ALMNAPPARGCYP2D6 | |
| SCHEMBL10062117 | 0.84 | ALOX15 (0.59) | MEN1KMT2ALMNAPPARGCYP2D6 | |
| SCHEMBL8459499 | 0.84 | THRB (0.52) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL12808488 | 0.82 | THRB (0.70) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL11981918 | 0.81 | ALDH1A1 (0.45) | MEN1KMT2ALMNAPPARGCYP2D6 | |
| SCHEMBL6041031 | 0.81 | SIRT5 (0.50) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL17771942 | 0.80 | CA2 (0.49) | CYP2D6TSHRUSP2HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293512-B2 | Polypeptide having activity of aminoacyl-tRNA synthetase and use thereof | RIKEN (JP) | 2012-10-23 | — | — | US | disclosed |
| US-20120028330-A1 | POLYPEPTIDE HAVING ACTIVITY OF AMINOACYL-tRNA SYNTHETASE AND USE THEREOF | RIKEN (JP) | 2012-02-02 | — | — | US | disclosed |
| US-8012739-B2 | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-09-06 | — | — | US | disclosed |
| US-20110190200-A1 | GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL pH BUFFERS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2011-08-04 | — | — | US | disclosed |
| US-20090227002-A1 | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs | THE SCRIPPS RESEARCH INSTITUTE and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-09-10 | — | — | US | disclosed |
| US-20090226966-A1 | Polypeptide having activity of aminoacyl-tRNA synthetase and use thereof | RIKEN (JP) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190200-A1 | GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL pH BUFFERS | GCG, GCGR, GLP1R | THRB 277/4885THRA 358/4885MEN1 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.