Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 3/20 | 0.52 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862016 | 0.86 | SLC5A1 (0.49) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6134453 | 0.81 | MAPT (0.53) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| SCHEMBL5801978 | 0.77 | SLC5A1 (0.47) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| SCHEMBL5204238 | 0.76 | HSD11B1 (0.47) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6133263 | 0.76 | HTR6 (0.49) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| SCHEMBL5204138 | 0.75 | MGLL (0.49) | HTR6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL5705151 | 0.75 | DRD2 (0.49) | HTR6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL6133727 | 0.74 | DRD2 (0.49) | HTR6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL5202048 | 0.74 | SLC2A1 (0.44) | SLC5A1SLC5A2HTR6ALDH1A1CYP1A2 | |
| SCHEMBL4862005 | 0.73 | SLC5A1 (0.51) | SLC5A1SLC5A2SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |