Potassium Ion

Potassium Ion

SCHEMBL5250400

O=C([O-])c1cccnc1Cl.[K+]

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA

The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
EGFR P00533 4/20 0.50
POLB P06746 1/20 0.49
L3MBTL1 Q9Y468 2/20 0.47
NPC1 O15118 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
CASP3 P42574 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
GFER P55789 1/20 0.45
GAA P10253 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
KDM4E B2RXH2 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium Ion SCHEMBL28965991 0.96 LMNA (0.66) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL28529875 0.96 LMNA (0.66) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL30137348 0.96 LMNA (0.66) LMNASMN1; SMN2EGFRPOLBL3MBTL1
Lithium Ion SCHEMBL30137319 0.96 LMNA (0.66) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL950218 0.81 LMNA (0.73) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL30792459 0.79 SMN1; SMN2 (1.00) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL29412848 0.79 SMN1; SMN2 (1.00) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL17180592 0.79 LMNA (0.70) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL105459 0.79 SMN1; SMN2 (0.70) LMNASMN1; SMN2EGFRPOLBL3MBTL1
SCHEMBL29799007 0.79 SMN1; SMN2 (0.70) LMNASMN1; SMN2EGFRPOLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115611802-B Synthetic method of 3-acetyl-2-chloropyridine 北京迪泰医药科技有限公司 2023-03-14 CN disclosed
CN-115611802-A Synthetic method of 3-acetyl-2-chloropyridine 北京迪泰医药科技有限公司 2023-01-17 CN disclosed
EP-1770093-A1 Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors Roche Palo Alto LLC (US) 2007-04-04 EP disclosed
EP-0631580-A1 PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1995-01-04 EP disclosed
US-5264437-A Antiinflammatory agents, immunosuppressants or antiallergens SYNTEX (U.S.A.) INC. (US) 1993-11-23 US disclosed
WO-1993019068-A1 PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1993-09-30 WO disclosed