Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331532 | 0.87 | ALDH1A1 (0.68) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL5902331 | 0.86 | NPC1 (0.65) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL2797868 | 0.86 | NPC1 (0.65) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL933858 | 0.84 | NPC1 (0.67) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL27909130 | 0.84 | ALDH1A1 (0.72) | NPC1ALDH1A1TSHRGAAPKM | |
| SCHEMBL14183972 | 0.84 | NPC1 (0.62) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL27909118 | 0.84 | ALDH1A1 (0.72) | NPC1ALDH1A1TSHRPKMPOLB | |
| SCHEMBL1695235 | 0.84 | NPC1 (0.66) | NPC1ALDH1A1TSHRGAARAB9A | |
| SCHEMBL6530877 | 0.83 | SMN1; SMN2 (0.69) | NPC1ALDH1A1GAARAB9APOLB | |
| SCHEMBL2795232 | 0.83 | NPC1 (0.61) | NPC1ALDH1A1TSHRGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045524-B2 | Pleuromutilin derivatives with antimicrobial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-05-16 | — | — | US | claimed |
| US-20050143393-A1 | Pleuromutilin derivatives with antimicrobial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-06-30 | — | — | US | claimed |
| EP-1355873-A1 | PLEUROMUTILIN DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2003-10-29 | — | — | EP | claimed |
| WO-2002038528-A1 | PLEUROMUTILIN DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-16 | — | — | WO | claimed |
| EP-1355873-B1 | PLEUROMUTILIN DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2007-07-25 | — | — | EP | disclosed |
| US-7045524-B2 | Pleuromutilin derivatives with antimicrobial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-05-16 | — | — | US | disclosed |
| US-20050143393-A1 | Pleuromutilin derivatives with antimicrobial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-06-30 | — | — | US | disclosed |
| EP-1355873-A1 | PLEUROMUTILIN DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002038528-A1 | PLEUROMUTILIN DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143393-A1 | Pleuromutilin derivatives with antimicrobial activity | PLEC, MLN, MRPL21 | NPC1 4333/4885ALDH1A1 1950/4885TSHR 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.