Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 3/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5249413 | 0.88 | DHODH (0.65) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3604109 | 0.85 | MEN1 (0.55) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL28282946 | 0.81 | LMNA (0.73) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL8693048 | 0.81 | ELANE (0.52) | LMNAMAPTNPC1RAB9AMEN1 | |
| SCHEMBL9496511 | 0.80 | LMNA (1.00) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL28949487 | 0.80 | LMNA (0.71) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL5083062 | 0.80 | RAB9A (0.72) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL29898238 | 0.80 | LMNA (0.71) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL5255345 | 0.80 | LMNA (0.71) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL28309786 | 0.80 | LMNA (0.71) | LMNAMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |