SCHEMBL525667

SCHEMBL525667

NC1(C(=O)O)CC1C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FABP5 Q01469 3/20 0.51
FABP7 O15540 2/20 0.51
KMT2A Q03164 2/20 0.46
EPHX2 P34913 1/20 0.43
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CASP3 P42574 2/20 0.37
DPP8 Q6V1X1 1/20 0.37
DPP9 Q86TI2 1/20 0.37
TSHR P16473 1/20 0.36
HTR2A P28223 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17699252 0.88 FABP5 (0.50) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL525363 0.87 FABP5 (0.49) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4600771 0.87 FABP5 (0.45) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL524690 0.86 FABP5 (0.48) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL7401416 0.85 FABP5 (0.47) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL1409924 0.83 FABP5 (0.43) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4601669 0.82 FABP5 (0.50) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL1157426 0.80 FABP5 (0.47) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4601031 0.80 FABP5 (0.45) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL18614244 0.78 FABP5 (0.46) FABP5FABP7KMT2AEPHX2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4605409-A2 CYCLIN INHIBITORS Circle Pharma, Inc. (US) 2025-08-27 EP disclosed
EP-4208466-B1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS UNIV DARMSTADT TECH (DE) 2025-06-11 EP disclosed
US-20240376154-A1 BIS-INTERCALATING PEPTIDES, CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-11-14 US disclosed
US-20240218021-A1 CYCLIN INHIBITORS CIRCLE PHARMA, INC. 2024-07-04 US disclosed
WO-2024086814-A2 CYCLIN INHIBITORS CIRCLE PHARMA, INC. (US) 2024-04-25 WO disclosed
US-11834463-B2 High affinity macrocyclic FKB51-inhibitors for treatment of psychiatric disorders Technische Universität Darmstadt (DE) 2023-12-05 US disclosed
EP-4208466-A1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS Technische Universität Darmstadt (DE) 2023-07-12 EP disclosed
US-20230212185-A1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS Technische Universität Darmstadt (DE) 2023-07-06 US disclosed
US-20230022534-A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS GALAPAGOS NV (BE) 2023-01-26 US disclosed
WO-2022049005-A1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS Technische Universität Darmstadt (DE) 2022-03-10 WO disclosed
WO-2002036616-A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2002-05-10 WO disclosed
WO-2002036807-A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS DIADEXUS, INC. (US) 2002-05-10 WO disclosed
US-20020048763-A1 Human genome-derived single exon nucleic acid probes useful for gene expression analysis AMERSHAM PLC (GB) 2002-04-25 US disclosed
US-20020048800-A1 Myosin-like gene expressed in human heart and muscle GE HEALTHCARE LIMITED (GB) 2002-04-25 US disclosed
WO-2002026818-A2 HUMAN NEDD-1 AEOMICA, INT. (US) 2002-04-04 WO disclosed
WO-2002024750-A2 HUMAN KIDNEY TUMOR OVEREXPRESSED MEMBRANE PROTEIN 1 AEOMICA, INC. (US) 2002-03-28 WO disclosed
CN-1051769-C Peptides NOVATIS INC (CH) 2000-04-26 CN disclosed
EP-0672057-A1 ANALOGS OF PTH Novartis AG (CH) 1995-09-20 EP disclosed
CN-1099801-A Peptides SANDOZ LTD (CH) 1995-03-08 CN disclosed
WO-1994002510-A2 ANALOGS OF PTH SANDOZ LTD. (CH) 1994-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230022534-A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS ENPP2, TPX2, PRXL2A FABP5 3671/4885FABP7 3739/4885KMT2A 1651/4885
US-20230212185-A1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS FKBP1B, FKBP5, FKBP1A FABP5 87/4885FABP7 20/4885KMT2A 1826/4885
US-20240218021-A1 CYCLIN INHIBITORS CCNI, CCNC, CDK2 FABP5 3119/4885FABP7 3683/4885KMT2A 1479/4885
US-11834463-B2 High affinity macrocyclic FKB51-inhibitors for treatment of psychiatric disorders FKBP1B, FKBP5, FKBP1A FABP5 87/4885FABP7 20/4885KMT2A 1826/4885
US-20240376154-A1 BIS-INTERCALATING PEPTIDES, CONJUGATES AND METHODS OF USE PCNA, POLI, VIP FABP5 1275/4885FABP7 1644/4885KMT2A 4145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.