SCHEMBL524690

SCHEMBL524690

NC1(C(=O)O)CCCCC1C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FABP5 Q01469 3/20 0.48
FABP7 O15540 2/20 0.48
KMT2A Q03164 2/20 0.43
EPHX2 P34913 1/20 0.41
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CASP3 P42574 2/20 0.35
MAPK1 P28482 1/20 0.35
OPRD1 P41143 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7401416 0.99 FABP5 (0.47) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL525363 0.96 FABP5 (0.49) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL17699252 0.93 FABP5 (0.50) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL289089 0.86 FABP5 (0.45) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL525667 0.86 FABP5 (0.51) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4601031 0.86 FABP5 (0.45) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL12987564 0.84 FABP5 (0.44) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL12987541 0.84 FABP5 (0.44) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4601669 0.84 FABP5 (0.50) FABP5FABP7KMT2AEPHX2CA1
SCHEMBL4654507 0.83 CTSL (0.40) FABP5FABP7KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637520-B2 Conjugation chemistry for catalytic antibody 38C2 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-26 US disclosed
US-20230012213-A1 NOVEL CONJUGATION CHEMISTRY FOR CATALYTIC ANTIBODY 38C2 THE SCRIPPS RESEARCH INSTITUTE 2023-01-12 US disclosed
CN-114846030-A Novel conjugation chemistry that catalyzes antibody 38C2 佛罗里达大学研究基金会公司 2022-08-02 CN disclosed
CN-111978371-B Polypeptide derivative and application thereof in field of medicine 成都诺和晟泰生物科技有限公司 2022-05-13 CN disclosed
CN-113788877-A Novel insect kinin analogs and application thereof in aphid control 中国农业大学 2021-12-14 CN disclosed
CN-108727468-B Cyclic peptide, pharmaceutical or cosmetic composition comprising the same, and preparation method thereof 陈建添 2021-12-03 CN disclosed
EP-3628677-B1 METHOD FOR PREPARING A CYCLOPEPTIDE UNIV NAT TSING HUA (TW) 2021-11-10 EP disclosed
EP-3392262-B1 CYCLOPEPTIDE, PHARMACEUTICAL OR COSMETIC COMPOSITION COMPRISING THE SAME AND METHOD FOR PREPARING THE SAME UNIV NAT TSING HUA (TW) 2021-08-18 EP disclosed
US-10851134-B2 Method for preparing cyclopeptide NATIONAL TSING HUA UNIVERSITY (TW) 2020-12-01 US disclosed
CN-111978371-A Polypeptide derivative and application thereof in field of medicine 成都诺和晟泰生物科技有限公司 2020-11-24 CN disclosed
WO-2002016407-A2 SH2 DOMAIN BINDING INHIBITORS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2002-02-28 WO disclosed
US-6331640-B1 TREATMENT OF REPERFUSION INJURIES HOFFMANN-LA ROCHE INC. 2001-12-18 US disclosed
US-20010016207-A1 Dipeptide nitrile cathepsin K inhibitors NOVARTIS AG (CH) 2001-08-23 US disclosed
WO-2001058886-A1 DIPEPTIDE NITRILE CATHEPSIN K INHIBITORS NOVARTIS AG (CH) 2001-08-16 WO disclosed
WO-2001058471-A2 NOVEL AMINO ACID AND PEPTIDE INHIBITORS OF STAPHYLOCOCCUS VIRULENCE INTERMUNE, INC. (US) 2001-08-16 WO disclosed
EP-1028942-A2 DIPEPTIDE NITRILES Novartis AG (CH) 2000-08-23 EP disclosed
WO-1999024460-A2 DIPEPTIDE NITRILES NOVARTIS AG (CH) 1999-05-20 WO disclosed
EP-0846127-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY Novartis AG (CH) 1998-06-10 EP disclosed
WO-1997008193-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY NOVARTIS AG (CH) 1997-03-06 WO disclosed
WO-1997007131-A1 ACYLATED OLIGOPEPTIDES CONTAINING PHOSPHOTYROSINE AS INHIBITORS OF PROTEIN TYROSINE KINASES NOVARTIS AG (CH) 1997-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10851134-B2 Method for preparing cyclopeptide PPIB, PPIA, PPIL1 FABP5 1058/4885FABP7 2753/4885KMT2A 4765/4885
US-12637520-B2 Conjugation chemistry for catalytic antibody 38C2 IGLV6-57, SETD1A, KDM4C FABP5 4767/4885FABP7 4798/4885KMT2A 5/4885
US-20230012213-A1 NOVEL CONJUGATION CHEMISTRY FOR CATALYTIC ANTIBODY 38C2 PTMS, MRPS34, SDC2 FABP5 4724/4885FABP7 4752/4885KMT2A 26/4885
US-20010016207-A1 Dipeptide nitrile cathepsin K inhibitors CTSK, CTSC, CTSS FABP5 4608/4885FABP7 3446/4885KMT2A 3931/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.