Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 5/20 | 0.35 |
| ▸ | MMP8 | P22894 | 5/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257452 | 0.90 | NPC1 (0.34) | MMP2MMP9MMP8MMP13HPSE | |
| Trifluoroacetic Acid SCHEMBL4843358 | 0.89 | ABL1 (0.44) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4838956 | 0.85 | SCD (0.42) | MMP2MMP9MMP8MMP13HPSE | |
| Trifluoroacetic Acid SCHEMBL4844349 | 0.85 | HPSE (0.36) | MMP2MMP9MMP8MMP13HPSE | |
| Trifluoroacetic Acid SCHEMBL4843563 | 0.84 | ALDH1A1 (0.41) | MMP2MMP9MMP8MMP13NPC1 | |
| Trifluoroacetic Acid SCHEMBL4842251 | 0.84 | TPH1 (0.37) | MMP2MMP9MMP8MMP13HPSE | |
| Trifluoroacetic Acid SCHEMBL4839496 | 0.84 | LDHA (0.38) | MMP2MMP9MMP8MMP13HPSE | |
| Trifluoroacetic Acid SCHEMBL4845670 | 0.83 | FFAR1 (0.42) | HPSEFFAR1 | |
| Trifluoroacetic Acid SCHEMBL4834113 | 0.83 | MMP2 (0.36) | MMP2MMP9MMP8MMP13NPC1 | |
| Trifluoroacetic Acid SCHEMBL4838725 | 0.83 | MMP2 (0.34) | MMP2MMP9MMP8MMP13HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |