Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689133 | 0.81 | POLB (0.61) | POLBSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL5263996 | 0.79 | CYP24A1 (0.59) | KDM4ESMN1; SMN2TDP1CYP24A1TP53 | |
| SCHEMBL5261127 | 0.79 | CNR1 (0.49) | KDM4EPOLBCSNK1D | |
| SCHEMBL5262774 | 0.77 | SLC6A9 (0.54) | KDM4ESMN1; SMN2TP53 | |
| SCHEMBL5265142 | 0.76 | FAAH (0.50) | KDM4EPOLBSMN1; SMN2MAPTHTT | |
| SCHEMBL5264318 | 0.76 | ALOX15 (0.56) | SMN1; SMN2MAPTHTTTDP1TP53 | |
| SCHEMBL5266049 | 0.76 | RAB9A (0.60) | KDM4ESMN1; SMN2MAPTHTTTP53 | |
| SCHEMBL5261544 | 0.75 | TLR7 (0.52) | KDM4EPOLB | |
| SCHEMBL5261739 | 0.74 | NPC1 (0.61) | — | |
| SCHEMBL5262900 | 0.74 | NSD2 (0.45) | KDM4ESMN1; SMN2HTTLMNACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |