Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 3/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.34 |
| ▸ | RBP4 | P02753 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262083 | 0.77 | SCD5 (0.34) | TRPC3TRPC6ALDH1A1RBP4TSHR | |
| SCHEMBL5263403 | 0.76 | FPR2 (0.48) | TRPC3TRPC6ALDH1A1USP2UBE2M | |
| SCHEMBL2186770 | 0.76 | ALDH1A1 (0.44) | TRPC3TRPC6ALDH1A1 | |
| SCHEMBL5262890 | 0.76 | HTR1A (0.42) | TRPC3TRPC6ALDH1A1USP2 | |
| SCHEMBL27709468 | 0.75 | POLB (0.43) | ALDH1A1USP2TDP1RBP4POLB | |
| SCHEMBL2187222 | 0.75 | TRPC3 (0.38) | TRPC3TRPC6ALDH1A1USP2TDP1 | |
| SCHEMBL2188215 | 0.75 | HCRTR1 (0.45) | TRPC3TRPC6ALDH1A1HSD11B1UBE2M | |
| SCHEMBL3060474 | 0.74 | POLB (0.42) | ALDH1A1USP2TDP1TSHRPOLB | |
| SCHEMBL2187194 | 0.73 | TSHR (0.49) | ALDH1A1TSHRPOLBMAPTHTT | |
| SCHEMBL2187029 | 0.73 | L3MBTL1 (0.46) | TRPC3TRPC6ALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1834954-A1 | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) | 4SC AG (DE) | 2007-09-19 | — | — | EP | disclosed |