Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 3/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316067 | 0.76 | TRPC3 (0.40) | USP2ALDH1A1TRPC3TRPC6UBE2M | |
| SCHEMBL2186770 | 0.76 | ALDH1A1 (0.44) | KMT2AALDH1A1TRPC3TRPC6MEN1 | |
| SCHEMBL5262890 | 0.75 | HTR1A (0.42) | USP2ALDH1A1TRPC3TRPC6DRD2 | |
| SCHEMBL27709468 | 0.74 | POLB (0.43) | USP2KMT2AALDH1A1MEN1HPGD | |
| SCHEMBL2187222 | 0.74 | TRPC3 (0.38) | USP2KMT2AALDH1A1TRPC3TRPC6 | |
| SCHEMBL2188215 | 0.74 | HCRTR1 (0.45) | ALDH1A1TRPC3TRPC6MGLLUBE2M | |
| SCHEMBL3060474 | 0.74 | POLB (0.42) | USP2KMT2AALDH1A1MEN1GAA | |
| SCHEMBL2187194 | 0.73 | TSHR (0.49) | KMT2AALDH1A1MEN1GAA | |
| SCHEMBL2187029 | 0.72 | L3MBTL1 (0.46) | PKMKMT2AALDH1A1TRPC3TRPC6 | |
| SCHEMBL2186868 | 0.71 | TDP1 (0.39) | KMT2AALDH1A1TRPC3TRPC6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1834954-A1 | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) | 4SC AG (DE) | 2007-09-19 | — | — | EP | disclosed |