Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709468 | 0.89 | POLB (0.43) | POLBTDP1MAPTUSP2ALDH1A1 | |
| SCHEMBL3061483 | 0.84 | F10 (0.38) | TDP1HRH3SPRAXLSCD | |
| SCHEMBL28020356 | 0.79 | SPR (0.44) | HRH3SPRSCDTSHR | |
| SCHEMBL2187222 | 0.78 | TRPC3 (0.38) | POLBTDP1MAPTUSP2ALDH1A1 | |
| SCHEMBL12467241 | 0.76 | HTR2B (0.42) | HRH3SPRSCDCYP2C19 | |
| SCHEMBL18711312 | 0.76 | SPR (0.47) | HRH3SPR | |
| SCHEMBL5262890 | 0.75 | HTR1A (0.42) | USP2ALDH1A1 | |
| SCHEMBL2186770 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5316067 | 0.74 | TRPC3 (0.40) | POLBTDP1MAPTUSP2ALDH1A1 | |
| SCHEMBL5263403 | 0.74 | FPR2 (0.48) | USP2ALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2009-12-10 | — | — | US | disclosed |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | 4SC AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | POLB 731/4885TDP1 3625/4885MAPT 4818/4885 |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | IL2, IL17A, IFNG | POLB 1075/4885TDP1 3754/4885MAPT 2853/4885 |
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | NFKBIA, NFKB2, IKBKB | POLB 288/4885TDP1 4129/4885MAPT 4579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.