Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | STS | P08842 | 9/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA9 | Q16790 | 3/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 3/20 | 0.62 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL5265400 | 1.00 | KDM4E (0.72) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL4995702 | 0.86 | LMNA (0.72) | KDM4ESTSABCC4ABCC1LMNA | |
| SCHEMBL7054352 | 0.86 | LMNA (0.72) | KDM4ESTSABCC4ABCC1LMNA | |
| SCHEMBL7054356 | 0.86 | LMNA (0.72) | KDM4ESTSABCC4ABCC1LMNA | |
| SCHEMBL15308955 | 0.86 | LMNA (0.72) | KDM4ESTSABCC4ABCC1LMNA | |
| Estradiol Disulfate SCHEMBL6409238 | 0.85 | STS (0.78) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL9747178 | 0.84 | ESR1 (0.76) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL2291502 | 0.84 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL4966962 | 0.84 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL9247669 | 0.84 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244458-B1 | WEIGHT PROMOTING COMPOSITION, METHOD, AND PRODUCT | PHERIN PHARM INC (US) | 2007-10-03 | — | — | EP | disclosed |
| US-6555531-B1 | Administering pregnanes such as 21-methyl-19-norpregna-1,3,5(10)-trien-3-ol; treating cachexia, eating disorders, AIDS, and giving to athletes | PHERIN PHARMACEUTICALS, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1244458-A2 | WEIGHT PROMOTING COMPOSITION, METHOD, AND PRODUCT | Pherin Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001049280-A2 | WEIGHT PROMOTING COMPOSITION, METHOD, AND PRODUCT | PHERIN PHARMACEUTICALS, INC. (US) | 2001-07-12 | — | — | WO | disclosed |