SCHEMBL5266004

SCHEMBL5266004

O=C(O)N1CCC(Oc2ncc(Cl)s2)CC1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SCD5 Q86SK9 1/20 0.35
EPHX2 P34913 7/20 0.34
SCD O00767 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2J2 P51589 2/20 0.34
HMOX1 P09601 1/20 0.34
CYP2C19 P33261 1/20 0.34
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
CHRM5 P08912 1/20 0.32
ACACB O00763 1/20 0.32
GPR119 Q8TDV5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5267504 0.83 HRH3 (0.43) SCD5CYP4F2CYP4A11
SCHEMBL5270564 0.82 GPR119 (0.51) GPR119
SCHEMBL5267119 0.75 HRH3 (0.39) SCD5EPHX2
SCHEMBL7107852 0.75 HRH3 (0.41) HMOX1
SCHEMBL5265331 0.74 GPR119 (0.46) EPHX2GPR119
SCHEMBL5318377 0.73 MMP1 (0.52) EPHX2GPR119
SCHEMBL8512089 0.73 LPL (0.51) EPHX2CYP4F2CYP4A11GPR119
SCHEMBL22361049 0.72 EGFR (0.44)
SCHEMBL289843 0.71 EGFR (0.41) SCD5EPHX2GPR119
SCHEMBL5155703 0.71 EPHX2 (0.57) SCD5EPHX2SCDCYP2C9CYP2J2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1347990-B1 Peptides having inhibiting activity to nitric oxyde production ASTELLAS PHARMA INC (JP) 2007-10-10 EP disclosed
US-7129243-B2 Peptide compounds ASTELLAS PHARMA INC. (JP) 2006-10-31 US disclosed
US-20040097425-A1 Peptide compounds ASTELLAS PHARMA INC. (JP) 2004-05-20 US disclosed
EP-1347990-A2 PEPTIDE MIT INHIBIERENDER AKTIVITÄT ZUR PRODUKTION VON STICKSTOFFMONOXID FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-10-01 EP disclosed
WO-2002055541-A2 PEPTIDES HAVING INHIBITING ACTIVITY ON THE PRODUCTION OF NITRIC OXIDE FUJISAWA PHARMACEUTICAL CO (JP) 2002-07-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040097425-A1 Peptide compounds VIP, NOS1, NOS3 SCD5 3546/4885EPHX2 3846/4885SCD 4019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.