Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | ALKBH2 | Q6NS38 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267243 | 0.87 | ALKBH2 (0.53) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL27985786 | 0.83 | BAZ2B (0.42) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5269393 | 0.83 | TSHR (0.47) | MAPTNPC1RAB9AKMT2AMAPK1 | |
| SCHEMBL5267207 | 0.79 | MLYCD (0.44) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL27986132 | 0.77 | ELANE (0.41) | MAPTNPC1HTTKMT2AMAPK1 | |
| SCHEMBL27745237 | 0.76 | TDP1 (0.53) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL15287294 | 0.75 | MAPT (0.48) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL9375079 | 0.75 | MAPT (0.50) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL7254281 | 0.74 | GAA (0.48) | ALKBH2HPGDSALDH1A1ITK | |
| SCHEMBL8313319 | 0.74 | KCNN4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025106014-A1 | COMPOUNDS AND METHODS FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2025-05-22 | — | — | WO | disclosed |
| CN-114846004-B | Antimalarial drugs | 德克萨斯大学系统董事会 | 2024-10-11 | — | — | CN | disclosed |
| US-11903936-B2 | Anti-malarial agents | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-02-20 | — | — | US | disclosed |
| US-20230056202-A1 | ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2023-02-23 | — | — | US | disclosed |
| CN-114846004-A | Novel antimalarial drug | 德克萨斯大学系统董事会 | 2022-08-02 | — | — | CN | disclosed |
| US-20070254881-A1 | Pyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-11-01 | — | — | US | disclosed |
| EP-1785418-A1 | PYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-16 | — | — | EP | disclosed |
| EP-1633306-A4 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO INC (US) | 2007-05-16 | — | — | EP | disclosed |
| EP-1633306-A2 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | Merck & Co., Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105698-A2 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO., INC. (US) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | PTGER1, PTGS1, PTGER2 | MAPT 4006/4885SMN1; SMN2 3490/4885NPC1 4323/4885 |
| US-11903936-B2 | Anti-malarial agents | PYCR1, DHFR, QDPR | MAPT 2471/4885SMN1; SMN2 3667/4885NPC1 2479/4885 |
| US-20230056202-A1 | ANTI-MALARIAL AGENTS | PYCR1, DHFR, QDPR | MAPT 2471/4885SMN1; SMN2 3667/4885NPC1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.