Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606362 | 0.78 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL3923958 | 0.74 | LMNA (0.40) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL25246994 | 0.74 | PGR (0.35) | — | |
| SCHEMBL28225381 | 0.74 | DAO (0.56) | ALDH1A1LMNAMAPK1MAPTHPGD | |
| SCHEMBL28297048 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL2305822 | 0.70 | MCL1 (0.51) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL7458964 | 0.70 | ALOX15 (0.48) | ALDH1A1MAPK1TSHRMAPTALOX15 | |
| SCHEMBL392578 | 0.68 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL21800159 | 0.67 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPK1TSHRMAPT | |
| SCHEMBL3175779 | 0.65 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPK1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| EP-3821947-A1 | HETEROCYCLIC TRPML1 AGONISTS | Libra Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20200317660-A1 | Quinazolinone Compound and Application Thereof | Luoxin Healthcare Science and Technology Development (Beijing) Ltd. (CN) | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | TRPM7, TRPM2, TRPM5 | ALDH1A1 2206/4885LMNA 2253/4885MAPK1 465/4885 |
| US-20200317660-A1 | Quinazolinone Compound and Application Thereof | PIK3CD, PIK3CA, PIK3R5 | ALDH1A1 1807/4885LMNA 3279/4885MAPK1 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.