Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274014 | 0.85 | ALDH1A1 (0.54) | LMNAKCNA5TSHRMEN1KMT2A | |
| SCHEMBL5270919 | 0.83 | KCNA5 (0.51) | KCNA5TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5269930 | 0.83 | KCNA5 (0.47) | KCNA5TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5270560 | 0.83 | LMNA (0.54) | NPC1RAB9ALMNAKCNA5ALDH1A1 | |
| SCHEMBL5270515 | 0.82 | EPHX1 (0.46) | NPC1RAB9AEPHX2LMNAEPHX1 | |
| SCHEMBL5268522 | 0.82 | LMNA (0.48) | NPC1RAB9ALMNAEPHX1KCNA5 | |
| SCHEMBL5273547 | 0.81 | TSHR (0.49) | LMNAKCNA5TSHRMEN1KMT2A | |
| SCHEMBL5265874 | 0.79 | SLC16A3 (0.48) | KCNA5TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5269318 | 0.79 | LMNA (0.53) | NPC1RAB9ALMNAKCNA5MEN1 | |
| SCHEMBL5268725 | 0.79 | RAB9A (0.51) | NPC1RAB9AKCNA5TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |