Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487543 | 0.79 | ALOX5 (0.39) | ALOX5MEN1KMT2APTGS1KDM4E | |
| SCHEMBL6475634 | 0.75 | MEN1 (0.48) | ALOX5MEN1KMT2APTGS1 | |
| SCHEMBL6477062 | 0.73 | HPGD (0.43) | ALOX5MEN1KMT2APTGS1KDM4E | |
| SCHEMBL6475630 | 0.72 | ALOX5 (0.45) | ALOX5MEN1KMT2AGAAPTGS1 | |
| SCHEMBL1394083 | 0.69 | PTGES (0.58) | ALOX5PTGS1PTGS2 | |
| SCHEMBL7479874 | 0.68 | ALOX5 (0.42) | ALOX5MEN1KMT2APTGS1KDM4E | |
| SCHEMBL10445152 | 0.65 | CYP2D6 (0.37) | ALOX5MEN1KMT2APTGS1PTGS2 | |
| SCHEMBL6483130 | 0.63 | PTGS2 (0.46) | PTGS1PTGS2 | |
| SCHEMBL1514634 | 0.62 | KMT2A (0.76) | ALOX5MEN1KMT2AGAAPTGS1 | |
| SCHEMBL9458579 | 0.60 | ALOX5 (1.00) | ALOX5MEN1KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861404-A1 | POLYMORPHIC FORM OF 6- (4-CHLOROPHENYL) -2, 2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-LH-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100019-A1 | POLYMORPHIC FORM OF 6- (4-CHLOROPHENYL) -2, 2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-LH-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |