Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154274 | 0.84 | GRM5 (0.47) | GRIA1GRIK1GRIA2GRIA4GRIA3 | |
| SCHEMBL6537411 | 0.81 | KMO (0.36) | GRIA1GRIK1GRIA2GRIA4GRIA3 | |
| SCHEMBL107537 | 0.81 | GRIA1 (0.35) | GRIA1GRIK1GRIA2GRIA4GRIA3 | |
| SCHEMBL16247195 | 0.80 | APAF1 (0.46) | GRIA1GRIK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL667079 | 0.79 | ALDH1A1 (0.33) | GRIA1GRIK1ALDH1A1 | |
| SCHEMBL2899641 | 0.75 | APEX1 (0.48) | GRIA1GRIA2GRIA4GRIA3KDM4E | |
| SCHEMBL28861793 | 0.75 | TSHR (0.43) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL26779833 | 0.75 | CDK4 (0.39) | ALDH1A1 | |
| SCHEMBL26779812 | 0.75 | CDK4 (0.39) | ALDH1A1 | |
| SCHEMBL28838403 | 0.72 | GRM5 (0.37) | GRIA1GRIK1GRIA2GRIA4GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002469-A2 | THERAPEUTIC COMPOSITIONS AND METHODS USING TRANSFORMING GROWTH FACTOR-BETA MIMICS | BHATNAGAR RAJENDRA S (US) | 2007-01-04 | — | — | WO | disclosed |