Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528578 | 0.96 | ROCK2 (0.53) | ROCK2MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL528391 | 0.89 | MAPT (0.62) | ROCK2MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL528858 | 0.87 | ROCK2 (0.51) | ROCK2MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL527889 | 0.86 | ALDH1A1 (0.58) | MAPTHTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL527918 | 0.85 | HPGD (0.65) | ROCK2MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL529461 | 0.85 | MAPT (0.50) | ROCK2MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL528487 | 0.83 | MAPT (0.46) | MAPTHTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL528300 | 0.82 | MAPT (0.63) | MAPTHTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL528399 | 0.82 | MAPT (0.56) | MAPTHTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL528511 | 0.81 | KMT2A (0.52) | MAPTHTTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |