Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | IL6 | P05231 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAX | P61244 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494559 | 0.80 | NFKB1 (0.55) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL323188 | 0.78 | NFKB1 (0.53) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3647881 | 0.78 | NFKB1 (0.53) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL637114 | 0.78 | NFKB1 (0.53) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL165004 | 0.76 | NFKB1 (0.52) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5544464 | 0.76 | NFKB1 (0.52) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5544458 | 0.76 | NFKB1 (0.52) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL67207 | 0.76 | NFKB1 (0.57) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11126093 | 0.76 | NFKB1 (0.57) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2154641 | 0.76 | NFKB1 (0.52) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001335-A2 | RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS INC. (US) | 2007-01-04 | — | — | WO | claimed |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS INC. (US) | 2006-09-21 | — | — | US | claimed |
| US-7105648-B1 | Oligomers substituted by phosphite acid ester, phosphonic acid or carbaborane functions and the corresponding PNA monomers | UGICHEM GMBH (AU) | 2006-09-12 | — | — | US | claimed |
| EP-1157031-B1 | OLIGOMERS SUBSTITUTED BY PHOSPHONIC ACID ESTER, PHOSPHONIC ACID OR CARBABORANE FUNCTIONS AND THE CORRESPONDING PNA MONOMERS | UGICHEM GMBH (AT) | 2003-12-17 | — | — | EP | claimed |
| EP-0793674-B1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH INC (US) | 2000-05-24 | — | — | EP | claimed |
| EP-0799186-A4 | 1,4,4-(TRISUBSTITUTED)CYCLOHEX-1-ENE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-03-25 | — | — | EP | claimed |
| EP-0799186-A1 | 1,4,4-(TRISUBSTITUTED)CYCLOHEX-1-ENE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | claimed |
| EP-0793674-A1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH, INC. (US) | 1997-09-10 | — | — | EP | claimed |
| WO-1996020162-A1 | 1,4,4-(TRISUBSTITUTED)CYCLOHEX-1-ENE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | claimed |
| WO-1996016080-A1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH, INC. (US) | 1996-05-30 | — | — | WO | claimed |
| WO-2007001335-A2 | RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS INC. (US) | 2006-09-21 | — | — | US | disclosed |
| US-7105648-B1 | Oligomers substituted by phosphite acid ester, phosphonic acid or carbaborane functions and the corresponding PNA monomers | UGICHEM GMBH (AU) | 2006-09-12 | — | — | US | disclosed |
| US-6509463-B1 | Isocyanoalkylcarbonic acid derivatives, the reaction thereof in isocyanide multicomponent reactions to form sec-amido-alkylcarbonic acid derivatives, and those sec-amidoalkyl-carbonic acid derivatives | UGICHEM GMBH (DE) | 2003-01-21 | — | — | US | disclosed |
| US-6147240-A | Isocyanoalkyl carbonic acid derivatives, their conversion into secondary amidoalkyl carbonic acid derivatives by isocyanide-multicomponent reactions, as well as these secondary amidoalkyl carbonic acid derivatives | UGICHEM GMBH (DE) | 2000-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | CLSPN, LMAN2, RPN2 | NFKB1 4577/4885GRIN2D 4763/4885GRIN3B 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.