Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038173 | 0.81 | LMNA (0.45) | LMNAHSD17B10HPGDKMT2AMEN1 | |
| SCHEMBL5280644 | 0.74 | TPSAB1 (0.35) | LMNAHSD17B10KMT2AMEN1MAPT | |
| SCHEMBL6037996 | 0.71 | LMNA (0.53) | LMNAHSD17B10HPGDKMT2AMEN1 | |
| SCHEMBL5285824 | 0.71 | CHRM2 (0.35) | ALDH1A1 | |
| SCHEMBL25220163 | 0.70 | L3MBTL1 (0.45) | LMNAHSD17B10KMT2AMEN1RAB9A | |
| SCHEMBL6038031 | 0.69 | HTR2A (0.47) | LMNAHSD17B10HPGDKMT2AMEN1 | |
| SCHEMBL6038028 | 0.69 | LMNA (0.48) | LMNAHSD17B10HPGDGAAKMT2A | |
| SCHEMBL30446010 | 0.67 | L3MBTL1 (0.44) | LMNARAB9AMAPTTHRBL3MBTL1 | |
| SCHEMBL5276612 | 0.66 | MAPT (0.50) | LMNAHPGDKMT2AMEN1RAB9A | |
| SCHEMBL6038152 | 0.66 | MAPT (0.49) | LMNAGAAKMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | claimed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | claimed |