Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5292958 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL5280436 | 0.76 | POLB (0.37) | POLBPTGS2PTGS1THRBCYP2C9 | |
| SCHEMBL5294487 | 0.75 | POLB (0.39) | POLBPTGS2PTGS1HTTALDH1A1 | |
| SCHEMBL14624160 | 0.71 | HTT (0.35) | POLBPTGS2PTGS1THRBCYP2C9 | |
| SCHEMBL14624155 | 0.71 | KDM4E (0.33) | POLBPTGS2PTGS1CYP2C9HTT | |
| SCHEMBL5296183 | 0.69 | POLB (0.34) | POLBPTGS2PTGS1THRBCYP2C9 | |
| SCHEMBL5325697 | 0.68 | RAD51 (0.40) | PTGS2PTGS1THRBCYP2C9HTT | |
| SCHEMBL5331474 | 0.67 | PTGS2 (0.38) | PTGS2PTGS1THRBCYP2C9HTT | |
| SCHEMBL14622453 | 0.67 | CYP11B1 (0.43) | POLBHTTALDH1A1KDM4EGAA | |
| SCHEMBL5297375 | 0.65 | MEN1 (0.42) | POLBPTGS2CYP2C9HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007161-A2 | NOVEL BIO-ACTIVE DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007007161-A2 | NOVEL BIO-ACTIVE DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-01-18 | — | — | WO | disclosed |