Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13657721 | 0.84 | ACHE (0.62) | SIGMAR1ACHEBCHEMEN1USP2 | |
| SCHEMBL14042694 | 0.82 | HRH4 (0.46) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL12559393 | 0.81 | HRH4 (0.62) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL11119265 | 0.78 | HRH4 (0.45) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11625870 | 0.78 | HTR1A (0.44) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL141985 | 0.78 | HRH4 (0.71) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL14340724 | 0.74 | ACHE (0.45) | SIGMAR1ACHEBCHEMEN1USP2 | |
| SCHEMBL11877889 | 0.72 | HRH4 (0.49) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11665287 | 0.71 | CETP (0.39) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL10956962 | 0.71 | HTR2C (0.39) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8481547-B2 | Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-09 | — | — | US | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| US-20110152287-A1 | SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | US | disclosed |
| US-7501421-B2 | Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070281945-A1 | Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-12-06 | — | — | US | disclosed |
| EP-1636239-B1 | INDOLE DERIVATIVES WITH AN IMPROVED ANTIPSYCHOTIC ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-18 | — | — | EP | disclosed |
| US-4382935-A | Analgesic drug containing a derivative of benzylpiperazine | Buzas, Andre (FR) | 1983-05-10 | — | — | US | disclosed |
| EP-0034521-B1 | ANALGESIC DRUG CONTAINING 1-(3'-BENZOFURYL)-4-BENZYLPIPERAZINE AND PROCESS FOR ITS PREPARATION | Buzas, André (FR) | 1983-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281945-A1 | Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | ADRB1 250/4885HTR3E 15/4885HTR3B 5/4885 |
| US-20110152287-A1 | SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | DPP4, DPP7, DPP3 | ADRB1 354/4885HTR3E 574/4885HTR3B 1020/4885 |
| US-20120289495-A1 | COMPOUNDS AND METHODS | XDH, CCNY, TOP2B | ADRB1 1245/4885HTR3E 515/4885HTR3B 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.