Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Creatine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 13/20 | 0.39 |
| ▸ | CA2 | P00918 | 13/20 | 0.39 |
| ▸ | EYA2 | O00167 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MVD | P53602 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatine SCHEMBL21810557 | 1.00 | NOS3 (0.44) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL29013915 | 1.00 | NOS3 (0.44) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL29019852 | 0.98 | NOS3 (0.43) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL28155161 | 0.98 | NOS3 (0.43) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL9391265 | 0.98 | NOS3 (0.43) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL20292685 | 0.98 | NOS3 (0.43) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL31274129 | 0.98 | NOS3 (0.43) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL30063981 | 0.98 | — | — | |
| Creatine SCHEMBL21567 | 0.98 | — | — | |
| Creatine SCHEMBL27979093 | 0.98 | NOS3 (0.46) | NOS3NOS1NOS2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3101 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636293-B2 | Methods of treating charcot-marie-tooth disease | CMTX BIOTECH INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-224242787-U | Creatine monohydrate mother liquor treatment system | 宁夏恒康科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4522144-B1 | COMPOSITION COMPRISING CREATINE FOR USE IN THE TREATMENT OF BREATHING DIFFICULTIES | ALZCHEM TROSTBERG GMBH (DE) | 2026-03-11 | — | — | EP | claimed |
| US-12568993-B2 | Shelf-stable nitrogenous organic acid compositions | GLANBIA DAIRY NUTRITION LIMITED (IE) | 2026-03-10 | — | — | US | claimed |
| US-12568991-B2 | Method for increasing the solubility and stability of organic compositions | GLANBIA DAIRY NUTRITION LIMITED (IE) | 2026-03-10 | — | — | US | claimed |
| US-12543767-B2 | Oral supplements containing enriched phenolic compound extracts combined with organic acid sodium salts, creatines and/or creatine salts | PHENOLICS, LLC | 2026-02-10 | — | — | US | claimed |
| WO-2025264604-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | THE PROCTER & GAMBLE COMPANY (US) | 2025-12-26 | — | — | WO | claimed |
| US-20250381110-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | PROCTER & GAMBLE (US) | 2025-12-18 | — | — | US | claimed |
| US-20250359578-A1 | WATER-SOLUBLE CREATINE AGGLOMERATE | ALZCHEM TROSTBERG GMBH (DE) | 2025-11-27 | — | — | US | claimed |
| WO-2025235746-A1 | NOVEL SOURCE OF MAGNESIUM AND CHOLINE AS A NOOTROPIC DIETARY SUPPLEMENT TO SUPPORT BRAIN AND NERVE HEALTH. | NUTRISOL LLC (US) | 2025-11-13 | — | — | WO | claimed |
| WO-1998004253-A1 | COMPOSITION OF PYRUVATE AND ANTI-CORTISOL COMPOUNDS AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | BEALE PAXTON K (US) | 1998-02-05 | — | — | WO | claimed |
| US-5683793-A | Ink jet transparencies | XEROX CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| US-5627172-A | ANTILIPEMIC AGENTS | NATURAL SUPPLEMENT ASSOCIATION, INCORPORATED (US) | 1997-05-06 | — | — | US | claimed |
| EP-0751388-A2 | Method of optically measuring a component in solution | Kyoto Dai-ichi Kagaku Co., Ltd. (JP) | 1997-01-02 | — | — | EP | claimed |
| US-5589277-A | INK JET PRINTING, AQUEOUS INKS, FAST DRYING | XEROX CORPORATION (US) | 1996-12-31 | — | — | US | claimed |
| EP-0667246-A1 | Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds | XEROX CORPORATION (US) | 1995-08-16 | — | — | EP | claimed |
| EP-0030964-B1 | NEGATIVE CONTROL MEDIA FOR MICROBIOLOGIC BIOCHEMICAL TESTS | Flow Laboratories Inc. (US) | 1984-04-04 | — | — | EP | claimed |
| EP-0030964-A4 | NEGATIVE CONTROL MEDIA FOR MICROBIOLOGIC BIOCHEMICAL TESTS. | FLOW LAB (US) | 1981-11-11 | — | — | EP | claimed |
| EP-0030964-A1 | NEGATIVE CONTROL MEDIA FOR MICROBIOLOGIC BIOCHEMICAL TESTS. | FLOW LAB (US) | 1981-07-01 | — | — | EP | claimed |
| WO-1981000115-A1 | NEGATIVE CONTROL MEDIA FOR MICROBIOLOGIC BIOCHEMICAL TESTS | MINNESOTA MINING & MFG (US) | 1981-01-22 | — | — | WO | claimed |