Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5301989 | 0.79 | MAPT (0.55) | CTSBKCNA5PDE5APKMJAK2 | |
| SCHEMBL8134885 | 0.77 | PKM (0.61) | CTSBSMN1; SMN2PKMMAOAMAOB | |
| SCHEMBL18547825 | 0.76 | CTSB (0.61) | CTSBPKMJAK2MAOAMAOB | |
| SCHEMBL9537830 | 0.76 | TXNRD1 (0.52) | CTSBPKMMAOANPC1MAPT | |
| SCHEMBL1917607 | 0.73 | PIN1 (0.57) | CTSBKCNA5PKMJAK2MAOA | |
| SCHEMBL1693791 | 0.72 | JAK2 (0.40) | CTSBKCNA5PDE5APKMJAK2 | |
| SCHEMBL5306617 | 0.72 | PDE5A (0.41) | PDE5ASMN1; SMN2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8245922 | 0.72 | PDE5A (0.52) | PDE5A | |
| SCHEMBL8247724 | 0.71 | PDE5A (0.72) | SCN9AKCNA5PDE5AMAPK14MAPK13 | |
| SCHEMBL18380137 | 0.70 | HDAC1 (0.44) | SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020521-A1 | PYRIDOYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2007-02-22 | — | — | WO | disclosed |