Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 8/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5301989 | 0.81 | MAPT (0.55) | TXNRD1CTSBNPC1MAOAMAPT | |
| SCHEMBL8134885 | 0.79 | PKM (0.61) | CTSBNPC1MAOAMAPTRAB9A | |
| SCHEMBL28489675 | 0.78 | TXNRD1 (0.57) | TXNRD1PGK1S1PR4MAPTS1PR1 | |
| SCHEMBL9538090 | 0.77 | TXNRD1 (0.60) | TXNRD1NPC1MAPTMAPK1RAB9A | |
| SCHEMBL5296768 | 0.77 | MAOA (0.54) | TXNRD1CTSBMAOARAB9AMEN1 | |
| SCHEMBL20703984 | 0.77 | NPC1 (0.66) | TXNRD1NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL29599605 | 0.77 | NPC1 (0.66) | TXNRD1NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL9540087 | 0.76 | CTSB (0.58) | CTSBNPC1MAPTRAB9AMEN1 | |
| SCHEMBL5301730 | 0.76 | CTSB (0.49) | CTSBNPC1MAOAMAPTRAB9A | |
| SCHEMBL10654754 | 0.76 | TXNRD1 (0.55) | TXNRD1S1PR4MAPTS1PR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |