Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450404 | 0.83 | CCR1 (0.51) | CCR1CCR2CCR4PKMCYP19A1 | |
| SCHEMBL9525426 | 0.78 | KDM4E (0.50) | PKMCYP19A1STSALDH1A1HDAC1 | |
| SCHEMBL31005997 | 0.78 | PKM (0.44) | CCR1CCR2CCR4PKMCYP19A1 | |
| SCHEMBL14610826 | 0.76 | CCR1 (0.40) | CCR1CCR2CCR4MEN1ALDH1A1 | |
| SCHEMBL14610754 | 0.74 | CYP19A1 (0.46) | CCR1CCR2CCR4PKMCYP19A1 | |
| SCHEMBL994055 | 0.70 | CYP19A1 (0.57) | PKMCYP19A1MEN1KMT2AHDAC1 | |
| SCHEMBL6280404 | 0.69 | PKM (0.49) | PKMCYP19A1ALDH1A1HDAC1HDAC6 | |
| SCHEMBL11127500 | 0.69 | PDK1 (0.46) | ALDH1A1 | |
| SCHEMBL18138458 | 0.69 | TSHR (0.44) | ALDH1A1 | |
| SCHEMBL9747728 | 0.68 | CCR1 (0.55) | CCR1CCR2CCR4PKMCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |