SCHEMBL5307396

SCHEMBL5307396

ON=Cc1ccc(F)cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
GRIN2D O15399 4/20 0.39
GRIN3B O60391 4/20 0.39
GRIN1 Q05586 4/20 0.39
GRIN2A Q12879 4/20 0.39
GRIN2B Q13224 4/20 0.39
GRIN2C Q14957 4/20 0.39
GRIN3A Q8TCU5 4/20 0.39
IDO1 P14902 2/20 0.39
HCAR1 Q9BXC0 1/20 0.38
APP P05067 1/20 0.38
MAPT P10636 3/20 0.35
ALOX12 P18054 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1B1 Q16678 1/20 0.35
AR P10275 2/20 0.34
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5307395 1.00 ALDH1A1 (0.40) ALDH1A1LMNAL3MBTL1GRIN2DGRIN3B
SCHEMBL30292169 1.00 ALDH1A1 (0.40) ALDH1A1LMNAL3MBTL1GRIN2DGRIN3B
SCHEMBL17712949 0.81 IDO1 (0.42) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4880854 0.81 CES2 (0.46) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL541829 0.81 CES2 (0.46) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL17712950 0.81 IDO1 (0.42) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL1436520 0.80 HPGD (0.44) ALDH1A1LMNAL3MBTL1GRIN2DGRIN3B
SCHEMBL30292123 0.80 HPGD (0.44) ALDH1A1LMNAL3MBTL1GRIN2DGRIN3B
SCHEMBL1436519 0.80 HPGD (0.44) ALDH1A1LMNAL3MBTL1GRIN2DGRIN3B
SCHEMBL7806209 0.80 HPGD (0.44) ALDH1A1L3MBTL1GRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230322659-A1 STROBILURIN TYPE COMPOUNDS AND THEIR USE FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2023-10-12 US disclosed
CN-115803314-A Strobilurin-type compounds and their use for combating phytopathogenic fungi 巴斯夫欧洲公司 2023-03-14 CN disclosed
WO-2007034445-A2 NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY ACTELION PHARMACEUTICALS LTD (CH) 2007-03-29 WO disclosed
WO-2006064484-A1 AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2006-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230322659-A1 STROBILURIN TYPE COMPOUNDS AND THEIR USE FOR COMBATING PHYTOPATHOGENIC FUNGI SQOR, COX5B, COX5A ALDH1A1 4148/4885LMNA 3311/4885L3MBTL1 2065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.