Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14508418 | 0.85 | ALDH1A1 (0.37) | NLRP3SMN1; SMN2HPGDMGAMGAA | |
| SCHEMBL9832188 | 0.83 | NLRP3 (0.43) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL8913104 | 0.80 | NLRP3 (0.49) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL14508465 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDGAAPPARGMEN1 | |
| SCHEMBL9832361 | 0.74 | SMN1; SMN2 (0.41) | NLRP3SMN1; SMN2L3MBTL1HPGDKMT2A | |
| SCHEMBL14496794 | 0.73 | NLRP3 (0.43) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL9372436 | 0.73 | NLRP3 (0.43) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL11269011 | 0.72 | NLRP3 (0.45) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL14156297 | 0.71 | ALDH1A1 (0.44) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL16171348 | 0.71 | PPARG (0.57) | SMN1; SMN2L3MBTL1HPGDPPARGMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788324-A2 | NOVEL PYRROLE DERIVATIVES | University Of Leicester (GB) | 2014-10-15 | — | — | EP | claimed |
| WO-2013083975-A2 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2013-06-13 | — | — | WO | claimed |
| EP-2602248-A1 | Novel pyrrole compounds | University Of Leicester (GB) | 2013-06-12 | — | — | EP | claimed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2014-10-16 | — | — | US | disclosed |
| EP-2788324-A2 | NOVEL PYRROLE DERIVATIVES | University Of Leicester (GB) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013083975-A2 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2013-06-13 | — | — | WO | disclosed |
| EP-2602248-A1 | Novel pyrrole compounds | University Of Leicester (GB) | 2013-06-12 | — | — | EP | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | NLRP3 756/4885CA12 3307/4885CA1 2630/4885 |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | NLRP3 326/4885CA12 4244/4885CA1 4590/4885 |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | NLRP3 326/4885CA12 4244/4885CA1 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.