Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922440 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL9919056 | 0.82 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL9919055 | 0.80 | CHEK1 (0.56) | KDM4ECHEK1FLT3SYK | |
| SCHEMBL9919064 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL12160615 | 0.77 | CHEK1 (0.45) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL7600928 | 0.77 | L3MBTL1 (0.49) | KDM4EALDH1A1HPGDL3MBTL1CHEK1 | |
| SCHEMBL23109663 | 0.76 | RAB9A (0.53) | KDM4EALDH1A1HPGDHSD17B10IP6K1 | |
| SCHEMBL9919062 | 0.76 | SYK (0.44) | KDM4EALDH1A1HPGDHSD17B10CHEK1 | |
| SCHEMBL9919061 | 0.76 | SYK (0.45) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL5312155 | 0.76 | L3MBTL1 (0.48) | KDM4EALDH1A1HPGDL3MBTL1IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053352-A2 | PYRROLOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | KDM4E 3529/4885ALDH1A1 1594/4885HPGD 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.